FB2026_02 , released June 18, 2026
Allele: Dmel\FanclRNAi.UAS
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General Information
Symbol
Dmel\FanclRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0281762
Feature type
allele
Associated gene
Dmel\Fancl
Associated Insertion(s)
Carried in Construct
P{UAS-Fancl.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Marek and Bale, 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Marek and Bale, 2006)
Mutagen
in vitro construct
(Marek and Bale, 2006)
Progenitor genotype
Carried in construct
P{UAS-Fancl.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverse repeat targeting the second exon of Fancl.

(Marek and Bale, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Fancl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Fanconi anemia
      CEA
      (Marek and Bale, 2006)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing FancldsRNA.Scer\UAS under the control of Scer\GAL4ey.PU have no observable morphological defects. When exposed to four different cross-linking agents (diepoxybutane, mitomycin C, cisplatinum and nitrogen mustard) a greater proportion of flies have rough eyes compared to wild type controls, although the severity of the rough eye phenotype is less severe than when Fancd2dsRNA.Scer\UAS is expressed.

      (Marek and Bale, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      FanclRNAi.UAS, Scer\GAL4ey.PU is a non-enhancer of visible | chemical conditional phenotype of Fancd2RNAi.UAS, Scer\GAL4ey.PU

      (Marek and Bale, 2006)

      FanclRNAi.UAS, Scer\GAL4ey.PU is a non-enhancer of neoplasia | chemical conditional phenotype of Fancd2RNAi.UAS, Scer\GAL4ey.PU

      (Marek and Bale, 2006)

      FanclRNAi.UAS/Scer\GAL4ey.PU is a non-enhancer of chemical sensitive phenotype of Fancd2RNAi.UAS

      (Marek and Bale, 2006)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      FanclRNAi.UAS, Scer\GAL4ey.PU is a non-enhancer of eye | chemical conditional phenotype of Fancd2RNAi.UAS, Scer\GAL4ey.PU

      (Marek and Bale, 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of FancldsRNA.Scer\UAS is unable to enhance the severity of the rough eye phenotype seen when Fancd2dsRNA.Scer\UAS is expressed alone. The proportion of flies that display a rough eye phenotype is similar across both of the single mutants and the double mutant.

      (Marek and Bale, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      FanclRNAi.UAS
      FancldsRNA.Scer\UAS
      FancldsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)