FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Gprk2UAS.cCb
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General Information
Symbol
Dmel\Gprk2UAS.cCb
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct b of Chen
FlyBase ID
FBal0281844
Feature type
allele
Associated gene
Dmel\Gprk2
Associated Insertion(s)
Carried in Construct
P{UAS-Gprk2.Cb}
Key Links
Transgenic product class
cDNA
(Chen and Feany, 2005)
wild_type
(Chen and Feany, 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Chen and Feany, 2005)
wild_type
(Chen and Feany, 2005)
Mutagen
in vitro construct
(Chen and Feany, 2005)
Progenitor genotype
Carried in construct
P{UAS-Gprk2.Cb}
Cytology
Description

UASt regulatory sequences drive expression of the Gprk2 LD42147 cDNA.

(Chen and Feany, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gprk2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cFa
      (Chen and Feany, 2005)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The enhancement of neurotoxicity is proposed to be via phosphorylation of Hsap\SNCA at serine 129, which is increased when Gprk2 is overexpressed.

      (Chen and Feany, 2005)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Gprk2Scer\UAS.cCb under the control of Scer\GAL4GMR.PF does not result in retinal degeneration in the eye.

      (Chen and Feany, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Gprk2Scer\UAS.cCb enhances the loss of dorsomedial dopaminergic neurons which is seen in adults expressing Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4elav.PU, with cell loss being seen in 10 day old double mutant flies.

      Co-expression of Gprk2Scer\UAS.cCb and Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4GMR.PF results in marked cell loss in the retina as early as 10 days of age.

      Co-expression of Gprk2Scer\UAS.cCb and Hsap\SNCAS129A.Scer\UAS under the control of Scer\GAL4GMR.PF does not result in retinal degeneration in the eye.

      (Chen and Feany, 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gprk2Scer\UAS.cCb
      Gprk2UAS.cCb
      Name Synonyms
      Saccharomyces cerevisiae UAS construct b of Chen
      Secondary FlyBase IDs
        References (2)