FB2026_02 , released June 18, 2026
Allele: Dmel\MTF-1UAS.cSa
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General Information
Symbol
Dmel\MTF-1UAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0282051
Feature type
allele
Associated gene
Dmel\MTF-1
Associated Insertion(s)
Carried in Construct
P{UAS-MTF-1.S}
Key Links
Transgenic product class
wild_type
(Saini et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Saini et al., 2011)
Mutagen
in vitro construct
(Saini et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-MTF-1.S}
Cytology
Description

UAS regulatory sequences drive expression of full-length MTF-1 coding sequences.

(Saini et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
MTF-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by park25
      (Saini et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of MTF-1Scer\UAS.cSa under the control of Scer\GAL4Act5C.PI does not increase normal life span.

      (Saini et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      MTF-1UAS.cSa/Scer\GAL4Act5C.PI is a suppressor of short lived phenotype of park25

      (Saini et al., 2011)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Elevated expression of MTF-1, through expression of MTF-1Scer\UAS.cSa under the control of Scer\GAL4Act5C.PI prolongs the life span of park25 mutants significantly, with 10% of the mutant animals still alive at day 34. Elevated MTF-1 expression not only prolongs the life span of park25 mutant flies but also enhances survival during development.

      Expression of MTF-1Scer\UAS.cSa under the control of Scer\GAL4Act5C.PI rescues the defect in thoracic muscle fiber structure seen in park25 mutants. Muscle structure is more regular, with fewer prominent vacuoles and the mitochondria have more densely packed cristae with considerably fewer signs of disintegration in comparison to park25 mutants.

      (Saini et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MTF-1Scer\UAS.cSa
      MTF-1UAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)