FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MAPTS238A.T245A.UAS.2N4R.Tag:FLAG
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General Information
Symbol
Hsap\MAPTS238A.T245A.UAS.2N4R.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0282059
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
P{UAS-htau.STA.FLAG}
Key Links
Transgenic product class
missense_variant
(Kosmidis et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kosmidis et al., 2010)
Mutagen
in vitro construct
(Kosmidis et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-htau.STA.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of a Tag:FLAG-flagged "2N4R" isoform of Hsap\MAPT with amino acid substitutions S238A and T245A.

(Kosmidis et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MAPT
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEA
      (Papanikolopoulou and Skoulakis, 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Histological evaluation of the mushroom bodies in adults expressing Hsap\MAPTS238A.T245A.Scer\UAS.2N4R.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU throughout development does not reveal any obvious morphological defects.

      The associative olfactory learning performance of animals expressing Hsap\MAPTS238A.T245A.Scer\UAS.2N4R.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU is highly deficient compared with controls.

      Octanol avoidance of flies expressing Hsap\MAPTS238A.T245A.Scer\UAS.2N4R.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU is somewhat lower but not significantly different from controls, and responses to benzaldehyde are normal.

      (Kosmidis et al., 2010)

      Although expression of Hsap\MAPTS238A.T245A.Scer\UAS.2N4R.T:Zzzz\FLAG has no effect on mushroom body morphology, associative olfactory learning is impaired in adult animals expressing Hsap\MAPTScer\UAS.cWa under the control of Scer\GAL4elav.PU.

      (Papanikolopoulou et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MAPTS238A.T245A.Scer\UAS.2N4R.T:Zzzz\FLAG
      Hsap\MAPTS238A.T245A.UAS.2N4R.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)