FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ATP7RNAi.Sym.UAS
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General Information
Symbol
Dmel\ATP7RNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0282760
Feature type
allele
Associated gene
Dmel\ATP7
Associated Insertion(s)
Carried in Construct
P{UAS-ATP7.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Bahadorani et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Bahadorani et al., 2010)
Mutagen
in vitro construct
(Bahadorani et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-ATP7.RNAi}
Cytology
Description

UAS regulatory sequences positioned at either end of a fragment drive expression of nucleotides 2000-2900 of ATP7, in both sense and antisense orientation, resulting in the generation of dsRNA.

(Bahadorani et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ATP7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Menkes disease
      CEA
      (Bahadorani et al., 2010)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Menkes disease
      is ameliorated by MTF-1Tub.PY
      (Bahadorani et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ATP7dsRNA.Sym.Scer\UAS in the digestive tract under the control of Scer\GAL4NP2020 results in developmental arrest mainly at stage P12 of metamorphosis. Supplementation of copper into fly food enhances pupal survival into the adult stage.

      Animals expressing Scer\GAL4NP2020>ATP7dsRNA.Sym.Scer\UAS show severe neuro-developmental defects compared with controls, where the brain size in the mutant pupae is severely reduced to approximately half the size of that of wild-type.

      Surviving flies expressing Scer\GAL4NP2020>ATP7dsRNA.Sym.Scer\UAS display normal external morphology including cuticle pigmentation and bristle formation. The life span of these flies is only slightly shorter than that of controls. However, surviving flies are sensitised to oxidative stress in the form of hyperoxia.

      (Bahadorani et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of MTF-1Tub.PY in Scer\GAL4NP2020>ATP7dsRNA.Sym.Scer\UAS flies significantly enhances pupal survival.

      (Bahadorani et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ATP7RNAi.Sym.UAS
      ATP7dsRNA.Sym.Scer\UAS
      ATP7dsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)