FlyBase Allele Report: Dmel\MTF-1[Tub.PY]

General Information

Symbol

Dmel\MTF-1^Tub.PY

Species

D. melanogaster

Name

Tubulin promoter construct of Yepiskoposyan

FlyBase ID

FBal0216890

Feature type

allele

Associated gene

Dmel\MTF-1

Associated Insertion(s)

Carried in Construct

P{Tub-MTF-1.Y}

Also Known As

tub-MTF-1

Key Links

Transgenic product class

wild_type

(Yepiskoposyan et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yepiskoposyan et al., 2006)

Mutagen

in vitro construct

(Yepiskoposyan et al., 2006)

Progenitor genotype

Carried in construct

P{Tub-MTF-1.Y}

Cytology

Description

A Tubulin promoter drives expression of MTF-1.

(Yepiskoposyan et al., 2006)

Allele components

Component

Use(s)

Encoded product / tool

MTF-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Friedreich ataxia 1

modeled by fh^RNAi.UAS.cAa

(Soriano et al., 2016)

ameliorates Menkes disease

modeled by ATP7^RNAi.Sym.UAS

(Bahadorani et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response

(Bahadorani et al., 2010)

chemical resistant

(Bahadorani et al., 2010)

chemical sensitive

(Bahadorani et al., 2010)

short lived | chemical conditional

(Bahadorani et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ubiquitous expression of MTF-1^Tub.PY sensitises flies to zinc toxicity as compared with wild-type flies. Males expressing MTF-1^Tub.PY fed with zinc metal die at faster rate in comparison with wild-type flies but show no sensitivity or resistance on cadmium-supplemented medium relative to wild-type.

MTF-1^Tub.PY overexpression sensitises larvae to zinc overload but increases larval resistance to copper and ammonium tetrathiomolybdate (TTM) toxicity.

Ubiquitous overexpression of MTF-1^Tub.PY sensitises flies to starvation induced mortality.

(Bahadorani et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

MTF-1^Tub.PY is a suppressor of partially lethal - majority die | pharate adult stage P12 phenotype of ATP7^RNAi.Sym.UAS, Scer\GAL4^NP2020

(Bahadorani et al., 2010)

MTF-1^Tub.PY is a suppressor of chemical sensitive phenotype of Dpy-30L1^UAS.cVa, Scer\GAL4^Act.PU

(Vardanyan et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of MTF-1^Tub.PY in Scer\GAL4^NP2020>ATP7^{dsRNA.Sym.Scer\UAS} flies significantly enhances pupal survival.

(Bahadorani et al., 2010)

The increased sensitivity of flies expressing Dpy-30L1^Scer\UAS.cVa under the control of Scer\GAL4^Act to cadmium or zinc in the food medium is rescued by co-expression of MTF-1^Tub.PY.

(Vardanyan et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

MTF-1^Tub.PY

Name Synonyms

Tubulin promoter construct of Yepiskoposyan

Secondary FlyBase IDs

References (5)

Report Sections

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