FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\frayS347D.UAS
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General Information
Symbol
Dmel\frayS347D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0283038
Feature type
allele
Associated gene
Dmel\fray
Associated Insertion(s)
Carried in Construct
P{UAS-fray.S347D}
Also Known As
UAS-frayS347D
Key Links
Transgenic product class
missense_variant
(Sato and Shibuya, 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Sato and Shibuya, 2013)
Mutagen
in vitro construct
(Sato and Shibuya, 2013)
Progenitor genotype
Carried in construct
P{UAS-fray.S347D}
Cytology
Description

UAS regulatory sequences drive expression of constitutively active form of fray (contains the amino acid replacement S347D).

(Sato and Shibuya, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fray
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of frayS347D.Scer\UAS under the control of Scer\GAL4hh.PU results in additional veins around vein 5 and delta phenotypes at vein 4.

      Expression of frayS347D.Scer\UAS under the control of Scer\GAL4sd.PU does not result in a mutant phenotype in the abdomen.

      (Sato and Shibuya, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4hh.PU, frayS347D.UAS has visible phenotype, non-suppressible by Wnk[+]/WnkEY18

      (Sato and Shibuya, 2013)
      Suppressor of
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4hh.PU, frayS347D.UAS has wing vein | ectopic phenotype, non-suppressible by Wnk[+]/WnkEY18

      (Sato and Shibuya, 2013)

      Scer\GAL4hh.PU, frayS347D.UAS has wing vein L4 phenotype, non-suppressible by Wnk[+]/WnkEY18

      (Sato and Shibuya, 2013)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      WnkEY18/+ does not suppress the wing phenotypes (additional veins around vein 5 and delta phenotypes at vein 4) caused by expression of frayS347D.Scer\UAS under the control of Scer\GAL4hh.PU.

      Co-expression of frayS347D.Scer\UAS suppresses the defects in abdominal differentiation seen in pharate adults expressing WnkD420A.Scer\UAS under the control of Scer\GAL4sd.PU.

      Co-expression of frayS347D.Scer\UAS suppresses the peripheral nervous system defects seen in embryos expressing WnkD420A.Scer\UAS under the control of Scer\GAL4insc-Mz1407.

      (Sato and Shibuya, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      frayS347D.Scer\UAS
      frayS347D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)