FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\WnkEY18
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General Information
Symbol
Dmel\WnkEY18
Species
D. melanogaster
Name
FlyBase ID
FBal0283035
Feature type
allele
Associated gene
Dmel\Wnk
Associated Insertion(s)
P{5'EPgy2}WnkEY18
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Sato and Shibuya, 2013)
Progenitor genotype
P{EPgy2}WnkEY10165
(Sato and Shibuya, 2013)
Associated Insertion(s)
P{5'EPgy2}WnkEY18
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1712bp deletion extending from the insertion site to the middle of exon 3 (the deleted sequence includes the translation start site). 1365bp of the 5' part of the original insertion remains.

(Sato and Shibuya, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:21,553,013..21,554,724 [-]
Comment:

1712 bp deletion resulting from the imprecise excsion of P{EPgy2}WnkEY10165. 1365 bp of the insertion remain.

(Sato and Shibuya, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die between the late embryonic stage and the early second instar larval stage. Homozygous embryos show minor defects in axon guidance (penetrance approximately 15%).

      Large homozygous clones (generated using the Minute method) result in extra veins in the wing, loss of macrochaetae and microchaetae on the notum and in defects in abdominal development in pharate adults.

      (Sato and Shibuya, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Wnk[+]/WnkEY18 is a non-suppressor of visible phenotype of Scer\GAL4hh.PU, frayS347D.UAS

      (Sato and Shibuya, 2013)
      Phenotype Manifest In
      Suppressed by
      NOT Suppressor of
      Statement
      Reference

      Wnk[+]/WnkEY18 is a non-suppressor of wing vein | ectopic phenotype of Scer\GAL4hh.PU, frayS347D.UAS

      (Sato and Shibuya, 2013)

      Wnk[+]/WnkEY18 is a non-suppressor of wing vein L4 phenotype of Scer\GAL4hh.PU, frayS347D.UAS

      (Sato and Shibuya, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      WnkEY18/+ does not suppress the wing phenotypes (additional veins around vein 5 and delta phenotypes at vein 4) caused by expression of frayS347D.Scer\UAS under the control of Scer\GAL4hh.PU.

      Expression of AwhScer\UAS.cSa under the control of Scer\GAL4arm.PU in homozygous WnkEY18 clones (a Scer\GAL80 repressor is present to ensure expression is limited to within the clone) partially rescues the defects in abdominal development seen in pharate adults containing WnkEY18 clones.

      (Sato and Shibuya, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DWNKEY18
      (Sato and Shibuya, 2013)
      WnkEY18
      (Sato and Shibuya, 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)