FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lokkd.GUS
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General Information
Symbol
Dmel\lokkd.GUS
Species
D. melanogaster
Name
FlyBase ID
FBal0284056
Feature type
allele
Associated gene
Dmel\lok
Associated Insertion(s)
Carried in Construct
P{GUS-lok.kd}
Key Links
Transgenic product class
missense_variant
(Brodsky et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Brodsky et al., 2004)
Mutagen
in vitro construct
(Brodsky et al., 2004)
Progenitor genotype
Carried in construct
P{GUS-lok.kd}
Cytology
Description

A kinase-dead form of the lok coding region is expressed from both GMR and UAS regulatory sequences. The Asp at amino acid 303 has been replaced by Ala.

(Brodsky et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
UAS
Encoded product / tool
lok
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      lokkd.GUS/Scer\GAL4GMR.PU is a suppressor of visible phenotype of Scer\GAL4GMR.PU, p53GUS.PB

      (Brodsky et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      lokkd.GUS/Scer\GAL4GMR.PU is a suppressor of eye phenotype of Scer\GAL4GMR.PU, p53GUS.PB

      (Brodsky et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of lokkd.GUS suppresses the rough eye phenotype seen when p53GUS.PB is expressed under the control of Scer\GAL4GMR.PU.

      (Brodsky et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lokkd.GUS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)