FlyBase Allele Report: Hsap\MAPT[T175A.T181A.UAS]

General Information

Symbol

Hsap\MAPT^{T175A.T181A.UAS}

Species

H. sapiens

Name

FlyBase ID

FBal0284068

Feature type

allele

Associated gene

Hsap\MAPT

Associated Insertion(s)

Carried in Construct

P{UAS-tau.T175A.T181A}

Key Links

Transgenic product class

missense_variant

(Steinhilb et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Steinhilb et al., 2007)

Mutagen

in vitro construct

(Steinhilb et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-tau.T175A.T181A}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\MAPT carrying amino acid substitutions T175A and T181A.

(Steinhilb et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MAPT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^109(2)80

(Lin et al., 2010)

visible, with Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Phenotype Manifest In

dendritic arborizing neuron | third instar larval stage, with Scer\GAL4^109(2)80

(Lin et al., 2010)

eye, with Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Detailed Description

Statement

Reference

Expression of Hsap\MAPT^{T175A.T181A.Scer\UAS} in dendritic arborization (DA) neurons under the control of Scer\GAL4^109(2)80 strongly inhibits arborization.

(Lin et al., 2010)

Expression of Hsap\MAPT^{T175A.T181A.Scer\UAS} in the retina under the control of Scer\GAL4^GMR.PF results in a moderately rough eye.

(Steinhilb et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\MAPT^{T175A.T181A.UAS}, Scer\GAL4^109(2)80 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^109(2)80

(Lin et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\MAPT^{T175A.T181A.UAS}, Scer\GAL4^109(2)80 has dendritic arborizing neuron | third instar larval stage phenotype, enhanceable by Hsap\LRRK2^{G2019S.UAS.cLa.Tag:FLAG}, Scer\GAL4^109(2)80

(Lin et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

When co-expressed in dendritic arborization (DA) neurons, Hsap\LRRK2^{G2019S.Scer\UAS.cLa.T:Zzzz\FLAG} causes further dendrite degeneration in DA neurons that express Hsap\MAPT^{T175A.T181A.Scer\UAS}.

(Lin et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\MAPT^{T175A.T181A.Scer\UAS}

Hsap\MAPT^{T175A.T181A.UAS}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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