FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sicilyH
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General Information
Symbol
Dmel\sicilyH
Species
D. melanogaster
Name
FlyBase ID
FBal0284115
Feature type
allele
Associated gene
Dmel\sicily
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhang et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: W327term.

(Zhang et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,893,646..11,893,646 [+]
Nucleotide change:

G11893646A

Amino acid change:

W327term | sicily-PA; W327term | sicily-PB

Reported amino acid change:

W327term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhang et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies containing homozygous eyes (generated using the eyFLP method) show degenerative electroretinogram defects which worsen with age.

      (Zhang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sicilyEY02706

      (Zhang et al., 2013)
      Rescued by

      sicilyH is rescued by sicilymCherry

      (Zhang et al., 2013)

      sicilyH is rescued by Scer\GAL4da.PU/sicilyUAS.cZa

      (Zhang et al., 2013)
      Comments

      sicilyT:Disc\RFP-mCherry rescues the lethality and electroretinogram defects of sicilyH.

      (Zhang et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      XE07H
      (Zhang et al., 2013)
      sicilyH
      Name Synonyms
      Secondary FlyBase IDs
        References (1)