FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Abp1UAS.Tag:Myr(Src64B),GFP
Open Close
General Information
Symbol
Dmel\Abp1UAS.Tag:Myr(Src64B),GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0284214
Feature type
allele
Associated gene
Dmel\Abp1
Associated Insertion(s)
Carried in Construct
P{UAS-myrAbp1-GFP}
Key Links
Transgenic product class
wild_type
(Koch et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Koch et al., 2012)
Mutagen
in vitro construct
(Koch et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-myrAbp1-GFP}
Cytology
Description

UAS regulatory sequences drive expression of Abp1, which is tagged with a myristoylation motif (Tag:Myr(Src64B)) and with GFP.

(Koch et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Abp1
Tagged with
GFP
Tag:Myr(Src64B)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP under the control of Scer\GAL4sca.PU results in a split microchaete phenotype. The phenotype ranges from short microchaetes with multiple splits (at least 4 visible tips) to microchaetes with only one or two splits either occurring laterally or within the upper third of the microchaete. Ultrastructural analysis indicates the that split structures have a common base, with one nerve cell extension in the centre. Split microchaetae are also reduced in length compared to wild type, while the diameter at the base and volume are normal.

      (Koch et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Abp1UAS.Tag:Myr(Src64B),GFP, Scer\GAL4sca.PU has microchaeta phenotype, non-suppressible by WASp[+]/WASp1

      (Koch et al., 2012)

      Abp1UAS.Tag:Myr(Src64B),GFP, Scer\GAL4sca.PU has microchaeta phenotype, non-suppressible by WASp[+]/WASp3

      (Koch et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for either WASp1 or WASp3 does not suppress the split microchaete phenotype caused by expression of Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP under the control of Scer\GAL4sca.PU.

      Co-expression of Arp2dsRNA.Scer\UAS.cUa strongly suppresses the split microchaete phenotype caused by expression of Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP under the control of Scer\GAL4sca.PU.

      Heterozygosity for either SCARΔ37 or SCARk03107 suppresses the split microchaete phenotype caused by expression of Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP under the control of Scer\GAL4sca.PU.

      Co-expression of HemScer\UAS.T:Myr-Src64B enhances the split microchaete phenotype caused by expression of Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP under the control of Scer\GAL4sca.PU.

      (Koch et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP
      Abp1UAS.Tag:Myr(Src64B),GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)