FB2026_02 , released June 18, 2026
Allele: Dmel\HemUAS.Tag:Myr(Src64B)
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General Information
Symbol
Dmel\HemUAS.Tag:Myr(Src64B)
Species
D. melanogaster
Name
FlyBase ID
FBal0152477
Feature type
allele
Associated gene
Dmel\Hem
Associated Insertion(s)
Carried in Construct
P{UAS-Hem.Myr}
Also Known As
UAS-ketteMyr
Key Links
Transgenic product class
wild_type
(Bogdan and Klambt, 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bogdan and Klambt, 2003)
Mutagen
in vitro construct
(Bogdan and Klambt, 2003)
Progenitor genotype
Carried in construct
P{UAS-Hem.Myr}
Cytology
Description

Expression of the first 88 amino acids of Src64B fused to the full ORF of Hem, is under the control of UAS sequences.

(Bogdan and Klambt, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hem
Tagged with
Tag:Myr(Src64B)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HemScer\UAS.T:Myr-Src64B under the control of Scer\GAL4GMR.PU results in a rough eye phenotype. 40 hour pupal eye discs show disorganised F-actin patterning compared to wild-type controls.

      (Ku et al., 2009)

      Clones of cells expressing HemScer\UAS.T:Myr1 under the control of Scer\GAL4Act5C.PP in the wing disc grow equivalently to control clones. 4% of the cells expressing HemScer\UAS.T:Myr1 under the control of Scer\GAL4Act5C.PP are apoptotic (compared to 0.2% of control cells) and also 1% of neighbouring cells are apoptotic (compared to 0.3% of cells neighbouring control clones), survival of cells more than one cell diameter away is not affected. 81% of the dying cells adjacent to cells expressing HemScer\UAS.T:Myr1 under the control of Scer\GAL4Act5C.PP become engulfed by them (compared to 33% of dying cells engulfed into control cells).

      (Li and Baker, 2007)

      HemScer\UAS.T:Myr1; Scer\GAL4sca.PC flies have short, split microchaetae. Neuromuscular junctions in HemScer\UAS.T:Myr1; HemScer\UAS.T:Myr1 third instar larvae exhibit increased budding.

      (Bogdan et al., 2004)

      In HemScer\UAS.T:Myr1; Scer\GAL4Act5C.PHb transfected S2 cells F-actin accumulates close to the membrane. HemScer\UAS.T:Myr1)X3; Scer\GAL4sca-537.4 flies have shortened, thickened bristles, that are often forked. In addition, epidermal cells in these flies have multiple hairs emerging from each cell. (HemScer\UAS.T:Myr1)X2; Scer\GAL4sca-537.4 flies have similar but milder phenotypes. In (HemScer\UAS.T:Myr1)X3; Scer\GAL4sca-537.4 pupae, the apical F-actin cytoskeleton of bristle forming (thecogen) cells is disturbed: In contrast to wild type, large and irregular F-actin bundles emerge. In addition, the morphology of thecogen cells abnormal. These cells exhibit more irregular shapes and the cortical F-actin network appears fuzzy.

      (Bogdan and Klambt, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of HemScer\UAS.T:Myr-Src64B enhances the split microchaete phenotype caused by expression of Abp1Scer\UAS.T:Myr-Src64B,T:Avic\GFP under the control of Scer\GAL4sca.PU.

      (Koch et al., 2012)

      The rough eye phenotype caused by expression of HemScer\UAS.T:Myr-Src64B under the control of Scer\GAL4GMR.PU is enhanced by co-expression of either Ptp61FdsRNA.Scer\UAS.WIZ or AblScer\UAS.cFa and is suppressed by co-expression of either Ptp61Fm.Scer\UAS or AblK417N.Scer\UAS.

      The defects seen in F-actin organisation in 40 hour pupal eye discs of animals expressing HemScer\UAS.T:Myr-Src64B under the control of Scer\GAL4GMR.PU are increased significantly by co-expression of Ptp61FdsRNA.Scer\UAS.WIZ.

      (Ku et al., 2009)

      The short and split microchaetae phenotype of HemScer\UAS.T:Myr1; Scer\GAL4sca.PC flies is synergistically enhanced by Sra-1Scer\UAS.T:Myr1.

      (Bogdan et al., 2004)

      The bristle phenotype due to HemScer\UAS.T:Myr1; Scer\GAL4sca-537.4 is dominantly suppressed by WASp3.

      (Bogdan and Klambt, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HemScer\UAS.T:Myr-Src64B
      HemScer\UAS.T:Myr1
      HemUAS.Tag:Myr(Src64B)
      KetteMyr
      (Bogdan et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)