FB2026_02 , released June 18, 2026
Allele: Dmel\smoEW2
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General Information
Symbol
Dmel\smoEW2
Species
D. melanogaster
Name
FlyBase ID
FBal0284543
Feature type
allele
Associated gene
Dmel\smo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hooper, 2013.5.30)
Progenitor genotype
Cytology
Description

Amino acid replacement: S670L.

(Hooper, 2013.5.30)

The amino acid replacement mutates one of the Ser residues regulated by PKA.

(Hooper, 2013.5.30)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:280,411..280,413 [+]
Reported amino acid change:

S670L

Comment:

Nucleotide changes in at least two positions in the Ser codon (TCC) are required for the reported S670L amino acid change (the specific nucleotide changes were not reported). The Leu codon has been annotated as CTC. The position of the mutation on the genomic sequence was inferred by a FlyBase curator from the reported amino acid change.

(Hooper, 2013.5.30)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      smoEW2 is an enhancer of phenotype of ptcConf-1

      (Hooper, 2013.5.30)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      smoEW2
      (Hooper, 2013.5.30)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)