FlyBase Allele Report: Dmel\fws[Z1201]

General Information

Symbol

Dmel\fws^Z1201

Species

D. melanogaster

Name

FlyBase ID

FBal0284632

Feature type

allele

Associated gene

Dmel\fws

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Giansanti et al., 2004, Farkas et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: K230term.

(Farkas et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:17,480,161..17,480,161 [-]

Nucleotide change:

A17480161T

Amino acid change:

Reported amino acid change:

K230term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Farkas et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | male | recessive

(Giansanti et al., 2004)

abnormal meiotic cell cycle | male | recessive

(Giansanti et al., 2004)

abnormal mitotic cell cycle | male | recessive

(Giansanti et al., 2004)

male sterile | recessive

(Farkas et al., 2003)

Phenotype Manifest In

Nebenkern

(Giansanti et al., 2004)

spermatid & nucleus | supernumerary

(Giansanti et al., 2004)

Detailed Description

Statement

Reference

A large proportion of fws^Z1201 mutant spermatids have one large nebenkern with four nuclei of normal size, indicating a cytokinetic failure in both meiotic divisions. A smaller proportion have two nuclei and a large nebenkern, indicating failure of only one of the meiotic divisions. Occasionally spermatids are seen (<4% of cases) with three nuclei, which may be due to failure of cytokinesis in the first meiotic division, followed by budding off of only one daughter cell in the second meiotic division. Additionally, a significant proportion (19%) of spermatids have more than four nuclei, which may result from defects in the mitotic divisions preceding mitosis.

(Giansanti et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Giansanti

(Farkas et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fws^Z1201

(Belloni et al., 2012)

fws^z-1201

Name Synonyms

Secondary FlyBase IDs

FBal0179740
FBal0151903

References (3)

Report Sections

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