FB2026_02 , released June 18, 2026
Allele: Dmel\GlyRSteam
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General Information
Symbol
Dmel\GlyRSteam
Species
D. melanogaster
Name
FlyBase ID
FBal0284913
Feature type
allele
Associated gene
Dmel\GlyRS
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chihara et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: P98L.

(Chihara et al., 2007)

Nucleotide substitution: C?T.

(Chihara et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:15,095,554..15,095,554 [+]
Nucleotide change:

C15095554T

Reported nucleotide change:

C?T

Amino acid change:

P12L | GlyRS-PA; P98L | GlyRS-PB; P98L | GlyRS-PC

Reported amino acid change:

P98L

(Chihara et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dendritic terminals are completely missing in adult DL1 projection neuron homozygous single-cell clones, even though the dendritic stalks always show normal targeting to the vicinity of the DL1 glomerulus. The axons of these mutant neurons often do not reach the lateral horn (70% of cases), instead ending at the calyx region of the mushroom body with decreased numbers of synaptic boutons in the mushroom body calyx. In those cases (30%) where the mutant axon does reach the lateral horn, the axonal terminals are much less branched than normal.

      Homozygous anterodorsal neuroblast (adNb) and lNb clones also show loss of dendritic and axonal terminal arborisations in projection neurons. Homozygous adNb clones show a significant reduction in cell number compared to wild-type control adNb clones.

      (Chihara et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      GlyRSteam is rescued by GlyRSUAS.Tag:MYC/Scer\GAL4GH146

      (Chihara et al., 2007)
      Comments

      Expression of Aats-glyScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GH146 fully rescues the mutant phenotypes of homozygous Aats-glyteam DL1 projection neuron clones and of homozygous Aats-glyteam neuroblast clones.

      (Chihara et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Aats-glyteam
      GlyRSteam
      garsteam
      (Chihara et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)