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General Information
Symbol
Dmel\cpxUAS.7A
Species
D. melanogaster
Name
FlyBase ID
FBal0284955
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of the cpx 7A isoform.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Simultaneous expression of cpxE34A.UAS.7A and nSybK83A.UAS under the control of Scer\GAL4elav-C155 results in a significant decrease in the frequency of miniature excitatory postsynaptic currents, mESPCs, at the larval neuromuscular junction compared to larvae expressing cpxUAS.7A with nSybUAS.cLa, but the magnitude of this reduction is comparable to that observed for either cpxE34A.UAS.7A or nSybK83A.UAS relative to their counterpart wild-type transgene-overexpressing controls.

Scer\GAL4elav-C155-driven expression of cpxE34A.UAS.7A in the cpxSH1 background leads to reduced frequency of mESPCs at the larval NMJ compared to the rescue line expressing cpxUAS.7A but the amplitude as well as area of the evoked excitatory postsynaptic currents is comparable in both lines.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of cpxScer\UAS.7A under the control of Scer\GAL4elav-C155 fully rescues the elevation of spontaneous release and the reduction of EPSC amplitude seen at the neuromuscular junction in cpxSH1 third instar larvae.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
cpxScer\UAS.7A
cpxUAS.7A
Name Synonyms
Secondary FlyBase IDs
    References (2)