FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cpxUAS.7A
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General Information
Symbol
Dmel\cpxUAS.7A
Species
D. melanogaster
Name
FlyBase ID
FBal0284955
Feature type
allele
Associated gene
Dmel\cpx
Associated Insertion(s)
Carried in Construct
P{UAS-cpx.7A}
Key Links
Transgenic product class
wild_type
(Buhl et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Buhl et al., 2013)
Mutagen
in vitro construct
(Buhl et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-cpx.7A}
Cytology
Description

UAS regulatory sequences drive expression of the cpx 7A isoform.

(Buhl et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cpx
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of cpxE34A.UAS.7A and nSybK83A.UAS under the control of Scer\GAL4elav-C155 results in a significant decrease in the frequency of miniature excitatory postsynaptic currents, mESPCs, at the larval neuromuscular junction compared to larvae expressing cpxUAS.7A with nSybUAS.cLa, but the magnitude of this reduction is comparable to that observed for either cpxE34A.UAS.7A or nSybK83A.UAS relative to their counterpart wild-type transgene-overexpressing controls.

      Scer\GAL4elav-C155-driven expression of cpxE34A.UAS.7A in the cpxSH1 background leads to reduced frequency of mESPCs at the larval NMJ compared to the rescue line expressing cpxUAS.7A but the amplitude as well as area of the evoked excitatory postsynaptic currents is comparable in both lines.

      (Vasin et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/cpxUAS.7A rescues cpxSH1

      (Buhl et al., 2013)
      Comments

      Expression of cpxScer\UAS.7A under the control of Scer\GAL4elav-C155 fully rescues the elevation of spontaneous release and the reduction of EPSC amplitude seen at the neuromuscular junction in cpxSH1 third instar larvae.

      (Buhl et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cpxScer\UAS.7A
      cpxUAS.7A
      Name Synonyms
      Secondary FlyBase IDs
        References (3)