FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atac2UAS.cMa
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General Information
Symbol
Dmel\Atac2UAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ma
FlyBase ID
FBal0285291
Feature type
allele
Associated gene
Dmel\Atac2
Associated Insertion(s)
Carried in Construct
P{UAS-Atac2.M}
Key Links
Transgenic product class
wild_type
(Ma et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ma et al., 2013)
Mutagen
in vitro construct
(Ma et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Atac2.M}
Cytology
Description

UASt regulatory sequences drive expression of full length Atac2.

(Ma et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Atac2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Many of the midgut intestinal stem cells (ISCs) in flies expressing Atac2Scer\UAS.cMa under the control of Scer\GAL4esg-NP5130 (co-expressed with Avic\GFPScer\UAS.cUa, and restricted to two days post-eclosion using Scer\GAL80ts.αTub84B) are surrounded by patches of differentiated enteroendocrine and enterocyte cells that still retain some GFP expression. Three days after the temperature switch the number of mitotic cells (seen using PH3) is increased compared to controls, but has reduced to wild type levels by five days.

      Midgut clones expressing Atac2Scer\UAS.cMa under the control of Scer\GAL4esg-NP5130 still contain ISCs 10 days after induction, indicating that survival is not affected. However the clones contain an increased number of cells, having on average of 5.5 cells compared to 3.1 in controls.

      (Ma et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Atac2UAS.cMa/Scer\GAL4NP5130 rescues Atac2GD6972

      (Ma et al., 2013)
      Comments

      Expression of Atac2Scer\UAS.cMa rescues the increase in the number and size of midgut intestinal stem cell (ISC) clusters seen in flies expressing both Atac2GD6972 and Avic\GFPScer\UAS.cUa under the control of Scer\GAL4esg-NP5130. The ISCs are surrounded by differentiated enteroendocrine cells and enterocytes that retain some GFP expression.

      (Ma et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Atac2Scer\UAS.cMa
      Atac2UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ma
      Secondary FlyBase IDs
        References (1)