FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MAGERZ
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General Information
Symbol
Dmel\MAGERZ
Species
D. melanogaster
Name
FlyBase ID
FBal0285378
Feature type
allele
Associated gene
Dmel\MAGE
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Li et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q109term.

(Li et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:7,154,740..7,154,740 [-]
Nucleotide change:

C7154740T

Amino acid change:

Q109term | MAGE-PA

Reported amino acid change:

Q109term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Li et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant eyes (generated using the "EGUF" method) show morphological defects (moderate rough eye phenotype) when animals are raised on medium containing 2mM caffeine.

      MAGERZ/Df(3R)Antp1 animals show caffeine-dependent pupal lethality.

      Dramatically increased apoptotic cell death is observed in the eye discs of MAGERZ/MAGEXL larvae after 12 hours exposure to caffeine.

      MAGERZ/MAGEXL and MAGERZ/Df(3R)Antp1 animals show reduced survival after irradiation compared to controls.

      BrdU incorporation in eye imaginal discs is abolished by hydroxyurea treatment in MAGERZ/MAGEXL larvae, as occurs in wild type.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      MAGERZ has visible | somatic clone | conditional phenotype, enhanceable by mei-41RNAi.UAS.cUa/Scer\GAL4ey.PU

      (Li et al., 2013)

      MAGERZ has visible | somatic clone | conditional phenotype, enhanceable by tefuRNAi.UAS.cUa/Scer\GAL4ey.PU

      (Li et al., 2013)

      MAGERZ has chemical sensitive | somatic clone phenotype, enhanceable by tefuRNAi.UAS.cUa/Scer\GAL4ey.PU

      (Li et al., 2013)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      MAGERZ has eye | somatic clone | conditional phenotype, enhanceable by mei-41RNAi.UAS.cUa/Scer\GAL4ey.PU

      (Li et al., 2013)

      MAGERZ has eye | somatic clone | conditional phenotype, enhanceable by tefuRNAi.UAS.cUa/Scer\GAL4ey.PU

      (Li et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of either tefudsRNA.Scer\UAS.cUa or mei-41dsRNA.Scer\UAS.cUa under the control of Scer\GAL4ey.PU enhances the caffeine-dependent rough eye phenotype seen in homozygous MAGERZ eyes generated using the "EGUF" method.

      (Li et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MAGERZ
      sstRZ
      (Li et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)