FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MAGEXL
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General Information
Symbol
Dmel\MAGEXL
Species
D. melanogaster
Name
FlyBase ID
FBal0285379
Feature type
allele
Associated gene
Dmel\MAGE
Associated Insertion(s)
TI{TI}MAGEXL
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Li et al., 2013)
Mutagen
ends-out gene targeting
(Li et al., 2013)
Progenitor genotype
Associated Insertion(s)
TI{TI}MAGEXL
Cytology
Description

Deletion of the entire MAGE coding sequence. A single loxP site is present in place of the deleted sequence.

(Li et al., 2013)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:7,154,383..7,155,048 [-]
Comment:

Deletion of the MAGE coding sequence as a result of ends-out gene targeting.

(Li et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous, MAGEXL/MAGERZ and MAGEXL/Df(3R)Antp1 animals show caffeine-dependent lethality.

      Dramatically increased apoptotic cell death is observed in the eye discs of MAGERZ/MAGEXL larvae after 12 hours exposure to caffeine.

      Homozygous, MAGERZ/MAGEXL and MAGEXL/Df(3R)Antp1 animals show reduced survival after irradiation compared to controls.

      BrdU incorporation in eye imaginal discs is abolished by hydroxyurea treatment in MAGERZ/MAGEXL larvae, as occurs in wild type.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      MAGEXL is rescued by MAGE+t4

      (Li et al., 2013)
      Comments

      The caffeine-dependent lethality of MAGEXL is rescued by MAGE+t4.

      (Li et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MAGEXL
      sstXL
      (Li et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)