FB2026_02 , released June 18, 2026
Allele: Dmel\agoΔ3-7
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General Information
Symbol
Dmel\agoΔ3-7
Species
D. melanogaster
Name
FlyBase ID
FBal0285398
Feature type
allele
Associated gene
Dmel\ago
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Mortimer and Moberg, 2013)
Mutagen
P-element activity
(Mortimer and Moberg, 2013)
Progenitor genotype
P{EP}agoEP1135
(Mortimer and Moberg, 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 603bp deletion that removes the first exon of the ago-RC transcript.

(Mortimer and Moberg, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately 49% of homozygotes die as pupae and the remainder die as late second or third instar larvae.

      ago1/agoΔ3-7 third instar larvae have tracheal defects, with the most prevalent phenotype being an approximate doubling of the number of cytoplasmic branches elaborated from multiple subtypes of terminal cells, including the lateral LH and LG terminal cells. Other defects include terminal branch tangles and the development of 'ringlet'-shaped ganglionic branches, which are seen in approximately 25% of larvae.

      ago3/agoΔ3-7 third instar larvae have tracheal defects, with the most prevalent phenotype being an approximate doubling of the number of cytoplasmic branches elaborated from multiple subtypes of terminal cells, including the lateral LH terminal cells.

      agoEP1135/agoΔ3-7 flies recover significantly faster from hypoxia compared to wild-type controls.

      (Mortimer and Moberg, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      agoΔ3-7 has lethal phenotype, suppressible | partially by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago1 has lethal phenotype, suppressible | partially by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago3 has lethal phenotype, suppressible | partially by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      agoΔ3-7/ago1 has tracheole | increased number phenotype, suppressible by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago1 has tracheole phenotype, suppressible by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago1 has larval lateral H tracheal branch phenotype, suppressible by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago3 has larval lateral H tracheal branch phenotype, suppressible by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago3 has tracheole | increased number phenotype, suppressible by sima[+]/simaKG07607

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago1 has tracheole phenotype, suppressible by bnl[+]/bnl00857

      (Mortimer and Moberg, 2013)

      agoΔ3-7/ago1 has larval lateral H tracheal branch phenotype, suppressible by bnl[+]/bnl00857

      (Mortimer and Moberg, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      simaKG07607 dominantly delays the lethal phase of agoΔ3-7 homozygotes and of agoΔ3-7/ago1 and agoΔ3-7/ago3 transheterozygotes.

      simaKG07607 dominantly suppresses the excess and overlapping terminal tracheal branching seen in agoΔ3-7/ago1 larvae.

      bnl00857 dominantly suppresses the increase in number of terminal branches per lateral LH cell seen in ago1/agoΔ3-7 larvae.

      simaKG07607 dominantly suppresses the increase in number of terminal branches per lateral LH cell seen in ago3/agoΔ3-7 larvae.

      (Mortimer and Moberg, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      agoΔ3-7
      (Mortimer and Moberg, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)