FlyBase Allele Report: Dmel\HDAC11[RNAi.UAS]

General Information

Symbol

Dmel\HDAC11^RNAi.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0285819

Feature type

allele

Associated gene

Dmel\HDAC11

Associated Insertion(s)

Carried in Construct

P{UAS-HDAC11.RNAi}

Key Links

Transgenic product class

RNAi_reagent

(Todd et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Todd et al., 2010)

Mutagen

in vitro construct

(Todd et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-HDAC11.RNAi}

Cytology

Description

UAS regulatory sequences drive expression of a HDAC11 RNAi line.

(Todd et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

HDAC11

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived | dominant

(Pallos et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF is an enhancer of visible | heat sensitive phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

NOT Enhancer of

Statement

Reference

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-enhancer of short lived | calorie restriction conditional phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

NOT Suppressor of

Statement

Reference

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-suppressor of short lived | calorie restriction conditional phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF is an enhancer of eye | heat sensitive phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF is an enhancer of ommatidium | heat sensitive phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

HDAC11^RNAi.UAS, Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle | heat sensitive phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

NOT Enhancer of

Statement

Reference

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-enhancer of photoreceptor neuron phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-enhancer of rhabdomere phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

NOT Suppressor of

Statement

Reference

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-suppressor of photoreceptor neuron phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

HDAC11^RNAi.UAS, Scer\GAL4^elav-C155 is a non-suppressor of rhabdomere phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of HdacX^{dsRNA.Scer\UAS} exacerbates the Scer\GAL4^GMR.PF>Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP}-induced rough-eye phenotype.

(Todd et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

HDAC11^RNAi.UAS

HDAC11^{dsRNA.Scer\UAS}

HDAC11^dsRNA.UAS

HdacX^{dsRNA.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close