FlyBase Allele Report: Hsap\TRAP1[D158N.UAS]

General Information

Symbol

Hsap\TRAP1^D158N.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0286172

Feature type

allele

Associated gene

Hsap\TRAP1

Associated Insertion(s)

Carried in Construct

PBac{UAS-hTRAP1.D158N}

Key Links

Transgenic product class

missense_variant

(Zhang et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Zhang et al., 2013)

Mutagen

in vitro construct

(Zhang et al., 2013)

Progenitor genotype

Carried in construct

PBac{UAS-hTRAP1.D158N}

Cytology

Description

UAS regulatory sequences drive expression of an ATP-binding deficient form of Hsap\TRAP1 (contains the amino acid replacement D158N).

(Zhang et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\TRAP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Hsap\TRAP1^D158N.UAS, Scer\GAL4^da.G32 is a non-suppressor of lethal | heat sensitive phenotype of ND-15^GD4800, Scer\GAL4^da.G32

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of visible phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of abnormal flight phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS, Scer\GAL4^da.G32 is a non-suppressor of lethal phenotype of ND-MNLL^GD15316, Scer\GAL4^da.G32

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS, Scer\GAL4^da.G32 is a non-suppressor of lethal | heat sensitive phenotype of ND-MNLL^GD15546, Scer\GAL4^da.G32

(Zhang et al., 2013)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of wing phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of adult thorax phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of indirect flight muscle cell phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of mitochondrion phenotype of Pink1^B9

(Zhang et al., 2013)

Hsap\TRAP1^D158N.UAS/Scer\GAL4^da.G32 is a non-suppressor of mitochondrial crista phenotype of Pink1^B9

(Zhang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\TRAP1^{D158N.Scer\UAS} under the control of Scer\GAL4^da.G32 does not rescue the abnormal wing posture, thorax indentations, reduced climbing ability or reduction in flight ability seen in Pink1^B9/Y flies.

Expression of Hsap\TRAP1^{D158N.Scer\UAS} under the control of Scer\GAL4^da.G32 fails to rescue the vacuolisation and abnormal mitochondrial morphology seen in the indirect flight muscles of Pink1^B9/Y flies.

(Zhang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\TRAP1^{D158N.Scer\UAS}

Hsap\TRAP1^D158N.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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