FlyBase Allele Report: Dmel\Dscam1[576-isoform.x.y.8]

General Information

Symbol

Dmel\Dscam1^{576-isoform.x.y.8}

Species

D. melanogaster

Name

FlyBase ID

FBal0286274

Feature type

allele

Associated gene

Dmel\Dscam1

Associated Insertion(s)

TI{TI}Dscam1^{576-isoform.x.y.8}

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

gene targeting by homologous recombination

(Hattori et al., 2009)

FLPase

(Hattori et al., 2009)

Progenitor genotype

Associated Insertion(s)

TI{TI}Dscam1^{576-isoform.x.y.8}

Cytology

Description

Endogenous Dscam1 exons 7-11, which include the 33 exon 9 alternatives, are replaced with a cDNA encoding exons 7-11 which contains a single variant (variant 8) of exon 9, thus reducing the number of potential Dscam1 ectodomain isoforms from 19,008 to 576. (x.y.z in the allele symbol refers to combinations of exon 4, 6 and 9 respectively.). A single FRT site is present in the intron between exon 16 and exon 17.

(Hattori et al., 2009)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Hattori et al., 2009)

Phenotype Manifest In

dendritic arborizing neuron | larval stage

(Hattori et al., 2009)

mushroom body

(Hattori et al., 2009)

mushroom body (with Dscam1^{576-isoform.x.y.9})

(Hattori et al., 2009)

mushroom body (with Dscam1^{576-isoform.x.y.25})

(Hattori et al., 2009)

Detailed Description

Statement

Reference

Mutant (homozygous or heterozygous over a null allele) self dendrites of class I dendritic arborization neurons avoid each other as in wild type controls.

Mutant (homozygous or heterozygous over a null allele) self dendrites of class I and class III dendritic arborization neurons, which normally overlap, show significant avoidance.

Mutants only form a single mushroom body lobe.

Dscam^{576-isoform.x.y.8}/Dscam^{576-isoform.x.y.9} animals show abnormal mushroom body morphology: one lobe is absent or is thinner is the majority of these mutants.

Dscam^{576-isoform.x.y.8}/Dscam^{576-isoform.x.y.25} animals show abnormal mushroom body morphology: one lobe is absent or is thinner is the majority of these mutants.

Mutants have marked defects in the axonal branching patterns of posterior scutellar neurons.

Dscam^{576-isoform.x.y.8}/Dscam^{576-isoform.x.y.25} animals show defects in the axonal branching patterns of posterior scutellar neurons.

Dscam^{576-isoform.x.y.9}/Dscam^{576-isoform.x.y.8} animals show defects in the axonal branching patterns of posterior scutellar neurons.

(Hattori et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dscam1^{576-isoform.x.y.8}

Dscam1^576-isoform

(Hattori et al., 2009)

Dscam1^576-isoform (x.y.8)

(Hattori et al., 2009)

Dscam^{576-isoform.x.y.8}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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