FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rab11UAS.ORF.Tag:HA
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General Information
Symbol
Dmel\Rab11UAS.ORF.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0287523
Feature type
allele
Associated gene
Dmel\Rab11
Associated Insertion(s)
Carried in Construct
M{UAS-Rab11.ORF.3xHA}
Also Known As
UAS-Rab11-HA
Key Links
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
in vitro construct
(Schertel et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-Rab11.ORF.3xHA}
Cytology
Description

UASt regulatory sequences drive expression of a full-length Rab11 open reading frame which is tagged at the C-terminal end with three copies of Tag:HA.

(Schertel et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rab11
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APP2xAPP.SP.UAS
      (Yu et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of Rab11Scer\UAS.ORF.T:Ivir\HA1 under the control of Scer\GAL4da.G32 suppresses the reciprocal increased number of type Ib boutons and reciprocal decreased bouton size, and suppresses the reciprocal increased size and decreased number of synaptic vesicles and in the third instar larval neuromuscular junctions of Vps351/Vps35MH20 transheterozygotes.

      The expression of Rab11Scer\UAS.ORF.T:Ivir\HA1 under the control of Scer\GAL4ple.PF also suppresses the decreased sleep bouts displayed by Vps351 heterozygous adults.

      The expression of Rab5Scer\UAS.T:Avic\GFP under the control of Scer\GAL4da.G32 also suppresses the decreased locomotor activity (expression driven by Scer\GAL4da.G32) and the decreased excitatory junction potential amplitude under high stimulation conditions at the neuromuscular junctions (expression driven by Scer\GAL4Toll-6-D42), observed in Vps35MH20 heterozygous third instar larvae.

      (Inoshita et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rab11Scer\UAS.ORF.T:Ivir\HA1
      Rab11UAS.ORF.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)