FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HtrA21.97.S266A
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General Information
Symbol
Dmel\HtrA21.97.S266A
Species
D. melanogaster
Name
FlyBase ID
FBal0287647
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{HtrA21.97.S266A}
Key Links
Transgenic product class
missense_variant
(Yacobi-Sharon et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yacobi-Sharon et al., 2013)
Mutagen
in vitro construct
(Yacobi-Sharon et al., 2013)
Progenitor genotype
HtrA2+t1.97
(Yacobi-Sharon et al., 2013)
Carried in construct
P{HtrA21.97.S266A}
Cytology
Description

The serine at amino acid 266 of HtrA2 in HtrA2+t1.97 has been mutated to alanine.

(Yacobi-Sharon et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
HtrA2
Encoded product / tool
HtrA2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      HtrA21.97.S266A partially rescues HtrA2IFD/Df(3R)HtrA2Df1

      (Yacobi-Sharon et al., 2013)
      Comments

      Expression of two copies of HtrA21.97.S266A partially rescues the spermatogonial cyst death seen in HtrA2IFD/Df(3R)HtrA2Df1 mutant flies. The amount of germline cell death is restored to approximately 60% of wild type levels. The male sterility defect is also slightly rescued.

      (Yacobi-Sharon et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      HtrA21.97.S266A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)