FB2026_02 , released June 18, 2026
Allele: Dmel\Nrx-1ΔPBD.UAS
Open Close
General Information
Symbol
Dmel\Nrx-1ΔPBD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0287944
Feature type
allele
Associated gene
Dmel\Nrx-1
Associated Insertion(s)
Carried in Construct
P{UAS-Nrx-1.ΔPBD}
Key Links
Transgenic product class
inframe_deletion
(Sun et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Sun et al., 2009)
Mutagen
in vitro construct
(Sun et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Nrx-1.ΔPBD}
Cytology
Description

UAS regulates expression of wild type Nrx-1 using full-length cDNA clone LP14275 deleted for the PDZ binding domain.

(Sun et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nrx-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4RapGAP1-OK6/Nrx-1ΔPBD.UAS partially rescues Nrx-1273/Nrx-1Δ83

      (Li et al., 2015)
      Comments

      Expression of Nrx-1ΔPBD.Scer\UAS under the control of Scer\GAL4RapGAP1-OK6 fails to rescue the rapid synaptic depression, but does rescue the reduced mean EJCs and the reduced quantal content at the steady state seen in third instar Nrx-1273/Nrx-1Δ83 mutant NMJs under 1.8mM Ca[2+] conditions.

      Expression of Nrx-1ΔPBD.Scer\UAS under the control of Scer\GAL4RapGAP1-OK6 restores the decreased initial EJC amplitude and the reduced mean EJCs at the steady state observed in third instar Nrx-1273/Nrx-1Δ83 mutant NMJs under 0.5mM Ca[2+] conditions.

      (Li et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nrx-1ΔPBD.Scer\UAS
      Nrx-1ΔPBD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)