FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctr1CRNAi.UAS.cLa
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General Information
Symbol
Dmel\Ctr1CRNAi.UAS.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0288240
Feature type
allele
Associated gene
Dmel\Ctr1C
Associated Insertion(s)
Carried in Construct
P{UAS-Ctr1C.RNAi.L}
Key Links
Transgenic product class
RNAi_reagent
(Lang et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Lang et al., 2013)
Mutagen
in vitro construct
(Lang et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Ctr1C.RNAi.L}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of sequence corresponding to nucleotides 1-700 of the Ctr1C cDNA.

(Lang et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ctr1C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Lang et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      10 day old adults expressing Ctr1CdsRNA.Scer\UAS.cLa under the control of Scer\GAL4elav.PU show normal memory performance in an olfactory aversive conditioning assay.

      (Lang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Ctr1CdsRNA.Scer\UAS.cLa partially suppresses the climbing defects and reduced lifespan of adults expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU. The double mutant flies show defects in climbing ability starting at 30 days of age and show a 32.4% increase in median lifespan compared to Hsap\APPAβ1-42.Scer\UAS.cIa, Scer\GAL4elav.PU single mutant flies.

      Co-expression of Ctr1CdsRNA.Scer\UAS.cLa significantly decreases the neurodegeneration seen in the brains of 30 day old adults expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU.

      Co-expression of Ctr1CdsRNA.Scer\UAS.cLa does not rescue the impaired memory performance of 10 day old adults expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU in an olfactory aversive conditioning assay.

      Co-expression of Ctr1CdsRNA.Scer\UAS.cLa significantly increases the resistance of flies expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU to paraquat.

      (Lang et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ctr1CRNAi.UAS.cLa
      Ctr1CdsRNA.Scer\UAS.cLa
      Ctr1CdsRNA.UAS.cLa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)