FlyBase Allele Report: Dmel\His4[K16A.UAS]

General Information

Symbol

Dmel\His4^K16A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0288281

Feature type

allele

Associated gene

His4

Associated Insertion(s)

Carried in Construct

P{UAS-His4.K16A}

Key Links

Transgenic product class

missense_variant

(Lv et al., 2012)

polypeptide_post_translational_processing_variant

(Lv et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Lv et al., 2012)

polypeptide_post_translational_processing_variant

(Lv et al., 2012)

Mutagen

in vitro construct

(Lv et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-His4.K16A}

Cytology

Description

UASt regulatory sequences drive expression of His4 coding sequences carrying a mutation (amino acid replacement K16A) that renders the lysine at residue 16 incapable of acetylation.

(Lv et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

His4

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

His4^K16A.UAS, Scer\GAL4^GMR.PF is an enhancer of increased cell growth rate phenotype of Pi3K92E^UAS.Exel, Scer\GAL4^GMR.PF

(Lv et al., 2012)

Suppressor of

Statement

Reference

His4^K16A.UAS, Scer\GAL4^ey.PH is a suppressor | partially of decreased cell growth rate phenotype of HDAC3^RNAi.Sym.UAS, Scer\GAL4^ey.PH

(Lv et al., 2012)

His4^K16A.UAS, Scer\GAL4^ppl.PP is a suppressor | partially of decreased body size phenotype of HDAC3^RNAi.Sym.UAS, Scer\GAL4^ppl.PP

(Lv et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

His4^K16A.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Pi3K92E^UAS.Exel, Scer\GAL4^GMR.PF

(Lv et al., 2012)

His4^K16A.UAS, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Pi3K92E^UAS.Exel, Scer\GAL4^GMR.PF

(Lv et al., 2012)

Suppressor of

Statement

Reference

His4^K16A.UAS, Scer\GAL4^ey.PH is a suppressor | partially of eye phenotype of HDAC3^RNAi.Sym.UAS, Scer\GAL4^ey.PH

(Lv et al., 2012)

His4^K16A.UAS, Scer\GAL4^ey.PH is a suppressor | partially of ommatidium phenotype of HDAC3^RNAi.Sym.UAS, Scer\GAL4^ey.PH

(Lv et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of His4^{K16A.Scer\UAS} in a Hdac3^{dsRNA.Sym.Scer\UAS} background partially attenuates the Hdac3^{dsRNA.Sym.Scer\UAS}-induced decrease in eye size. Consistent with this finding, the reduction in body weight induced by Hdac3^{dsRNA.Sym.Scer\UAS} is also partially attenuated by co-expression of His4^{K16A.Scer\UAS}.

Co-expression of His4^{K16A.Scer\UAS} and Pi3K92E^{Scer\UAS.Exel} in the developing eye, under the control of Scer\GAL4^GMR.PF results in an increase in eye size and the ommatidial overgrowth phenotype found upon expression of Pi3K92E^{Scer\UAS.Exel} alone.

(Lv et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

His4^{K16A.Scer\UAS}

His4^K16A.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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