FB2026_02 , released June 18, 2026
Allele: Dmel\tank4-12
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General Information
Symbol
Dmel\tank4-12
Species
D. melanogaster
Name
FlyBase ID
FBal0288438
Feature type
allele
Associated gene
Dmel\tank
Associated Insertion(s)
P{GawB}tank4-12
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Devineni et al., 2013)
Mutagen
P-element activity
(Devineni et al., 2013)
Progenitor genotype
Associated Insertion(s)
P{GawB}tank4-12
Cytology
Description

P{GawB} insertion in an intron of the tank-RA isoform, upstream of the translation start site of both tank isoforms.

(Devineni et al., 2013)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant males and females show very strong resistance to ethanol sedation compared to controls when exposed to a high concentration of 67% ethanol vapour.

      Mutant males and females have a reduced internal ethanol concentration compared to controls after exposure to 47% ethanol. Dose-response experiments indicate that mutants require a higher internal ethanol concentration to show the same sedation sensitivity as control flies.

      (Devineni et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tank4-12 is rescued by Scer\GAL4tank-4-12/tankUAS.RA

      (Devineni et al., 2013)
      Comments

      Expression of tankScer\UAS.RA under the control of Scer\GAL4tank-4-12 restores the ethanol sensitivity of tank4-12 flies to wild type. This rescue is still seen if expression is restricted to the adult stage using the temperature sensitive Scer\GAL80ts.αTub84B allele.

      (Devineni et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P{GawB} element restores normal ethanol sensitivity.

      (Devineni et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tank4-12
      (Devineni et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)