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General Information
Symbol
Dmel\tank4-12
Species
D. melanogaster
Name
FlyBase ID
FBal0288438
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{GawB} insertion in an intron of the tank-RA isoform, upstream of the translation start site of both tank isoforms.

Insertion components
P{GawB}tank4-12
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant males and females show very strong resistance to ethanol sedation compared to controls when exposed to a high concentration of 67% ethanol vapour.

Mutant males and females have a reduced internal ethanol concentration compared to controls after exposure to 47% ethanol. Dose-response experiments indicate that mutants require a higher internal ethanol concentration to show the same sedation sensitivity as control flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of tankScer\UAS.RA under the control of Scer\GAL4tank-4-12 restores the ethanol sensitivity of tank4-12 flies to wild type. This rescue is still seen if expression is restricted to the adult stage using the temperature sensitive Scer\GAL80ts.╬▒Tub84B allele.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Precise excision of the P{GawB} element restores normal ethanol sensitivity.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)