FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF3mL
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General Information
Symbol
Dmel\eIF3mL
Species
D. melanogaster
Name
FlyBase ID
FBal0288454
Feature type
allele
Associated gene
Dmel\eIF3m
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(D'Brot et al., 2013)

hypomorphic allele - molecular evidence

(D'Brot et al., 2013)
Mutagen
ethyl methanesulfonate
(D'Brot et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: W358term.

(D'Brot et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:14,163,289..14,163,289 [-]
Nucleotide change:

G14163289A

Amino acid change:

W358term | eIF3m-PA; W358term | eIF3m-PB

Reported amino acid change:

W358term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(D'Brot et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      15% of homozygous Tango7L mutant flies have wrinkled wings. Mild wing blemishing and upward curved wings are seen at low penetrance.

      33% of Tango7L/Tango7E mutant flies have wrinkled wings. Most flies die during eclosion or soon thereafter. Mild wing blemishing and upward curved wings are seen at low penetrance.

      31% of Tango7L/Df(2R)Exel7130 mutant flies have wrinkled wings. Mild wing blemishing and upward curved wings are seen at low penetrance.

      The investment cones in the cystic bulges of homozygous Tango7L mutant spermatid cysts are able to form properly, but either stall at the nuclei or move asynchronously through the synctia.

      The investment cones in Tango7L/Tango7E mutant spermatid cysts are able to form properly, but either stall at the nuclei or move asynchronously through the synctia.

      (D'Brot et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      eIF3mL is rescued by eIF3m+tVK006

      (D'Brot et al., 2013)

      eIF3mE/eIF3mL is rescued by eIF3m+tVK006

      (D'Brot et al., 2013)
      Comments

      Expression of Tango7+tVK006 rescues the semi-viability, male sterility and wrinkled wing phenotypes seen in homozygous Tango7L mutants. Spermatid individualisation also occurs correctly.

      Expression of Tango7+tVK006 rescues the semi-viability, male sterility and wrinkled wing phenotypes seen in Tango7L/Tango7E mutants.

      (D'Brot et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Tango7L
      (D'Brot et al., 2013)
      eIF3mL
      tango7L
      (D'Brot et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)