FB2026_02 , released June 18, 2026
Allele: Dmel\HtrA2βTub85D.PY
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General Information
Symbol
Dmel\HtrA2βTub85D.PY
Species
D. melanogaster
Name
β-Tubulin at 85D promoter construct of Yun
FlyBase ID
FBal0288459
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{TMR-HtrA2.Y}
Key Links
Transgenic product class
wild_type
(Yun et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yun et al., 2008)
Mutagen
in vitro construct
(Yun et al., 2008)
Progenitor genotype
Carried in construct
P{TMR-HtrA2.Y}
Cytology
Description

Part of the regulatory region of βTub85D drives expression of HtrA2.

(Yun et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
βTub85D
Encoded product / tool
HtrA2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      HtrA2βTub85D.PY is a non-suppressor of sterile phenotype of Pink15

      (Yun et al., 2008)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      HtrA2βTub85D.PY is a non-suppressor of spermatid phenotype of Pink15

      (Yun et al., 2008)

      HtrA2βTub85D.PY is a non-suppressor of Nebenkern phenotype of Pink15

      (Yun et al., 2008)

      HtrA2βTub85D.PY is a non-suppressor of mitochondrial derivative phenotype of Pink15

      (Yun et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of HtrA2βTub85D.PY fails to suppress the mitochondrial morphology defects seen in Pink15 mutant spermatids. The spherical "onion stage" nebenkern contain vacuoles, and only one mitochondrial derivative is seen in "leaf blade stage" elongating spermatids. As in Pink15 mutants alone the flies are sterile.

      (Yun et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      HtrA2βTub85D.PY rescues HtrA2NSO/Df(3R)ED5644

      (Yun et al., 2008)
      Comments

      Expression of HtrA2βTub85D.PY rescues the spermatogenesis defects seen in HtrA2NSO/Df(3R)ED5644 mutant males. Motile sperm are present in the seminal vesicles and the individualisation defects are suppressed.

      (Yun et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HtrA2βTub85D.PY
      Name Synonyms
      β-Tubulin at 85D promoter construct of Yun
      Secondary FlyBase IDs
        References (1)