FB2026_02 , released June 18, 2026
Allele: Dmel\Pink1G426D
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General Information
Symbol
Dmel\Pink1G426D
Species
D. melanogaster
Name
FlyBase ID
FBal0288470
Feature type
allele
Associated gene
Dmel\Pink1
Associated Insertion(s)
Carried in Construct
P{Pink1.G426D}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Yun et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yun et al., 2008)
Mutagen
in vitro construct
(Yun et al., 2008)
Progenitor genotype
Pink1+tCa
(Yun et al., 2008)
Carried in construct
P{Pink1.G426D}
Cytology
Description

A genomic fragment containing a mutant form of Pink1 in which the glycine at amino acid 426 has been replaced by aspartic acid.

(Yun et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Pink1
Encoded product / tool
Pink1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:6,685,960..6,685,960 [+]
Nucleotide change:

G6685960A

Amino acid change:

G426D | Pink1-PA; G426D | Pink1-PB; G426D | Pink1-PC; G426D | Pink1-PD; G426D | Pink1-PE; G426D | Pink1-PF; G426D | Pink1-PG; G426D | Pink1-PH; G426D | Pink1-PI

Reported amino acid change:

G426D

Comment:

Analogous mutation in human PINK1 implicated in Parkinson disease 6; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.

(Yun et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Yun et al., 2008)
      PINK1:p.Gly309Asp
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: PINK1_2404
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Pink1G426D fails to rescue Pink15

      (Yun et al., 2008)
      Comments

      Expression of Pink1G426D fails to rescue the male sterility, indirect flight muscle degeneration and mitochondrial defects seen in Pink15 mutant flies.

      (Yun et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pink1G426D
      Name Synonyms
      Secondary FlyBase IDs
        References (2)