FlyBase Allele Report: Dmel\ato[RNAi.UAS.J]

General Information

Symbol

Dmel\ato^RNAi.UAS.J

Species

D. melanogaster

Name

FlyBase ID

FBal0288763

Feature type

allele

Associated gene

Dmel\ato

Associated Insertion(s)

Carried in Construct

P{UAS-ato.RNAi.J}

Key Links

Transgenic product class

RNAi_reagent

(Bossuyt et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Bossuyt et al., 2009)

Mutagen

in vitro construct

(Bossuyt et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-ato.RNAi.J}

Cytology

Description

UAS regulates expression of RNAi targeting ato.

(Bossuyt et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

ato

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Delta^UAS.cDa

(Bossuyt et al., 2009)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ato^RNAi.UAS.J, Scer\GAL4^ey.PH is an enhancer of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, ato^RNAi.UAS.J has neoplasia phenotype

(Bossuyt et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

ato^RNAi.UAS.J, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, ato^RNAi.UAS.J has eye phenotype

(Bossuyt et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of ato^{dsRNA.Scer\UAS.J} results in a dramatic increase in tumour and metastases incidence in 'eyeful' (Scer\GAL4^ey.PH, Dl^Scer\UAS.cDa, psq^GS88A8, lola^GS88A8) flies.

Co-expression of ato^{dsRNA.Scer\UAS.J} in a Scer\GAL4^ey.PH Dl^Scer\UAS.cDa background leads to tumors in 0.5% of eyes, with 0.3% of flies showing metastasis (mostly present in the thorax and head).

(Bossuyt et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Stated as a "gift from A. P. Jarman".

(Bossuyt et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ato^RNAi.UAS.J

ato^{dsRNA.Scer\UAS.J}

ato^dsRNA.UAS.J

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close