FB2026_02 , released June 18, 2026
Allele: Dmel\Obp49aD
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General Information
Symbol
Dmel\Obp49aD
Species
D. melanogaster
Name
FlyBase ID
FBal0290242
Feature type
allele
Associated gene
Dmel\Obp49a
Associated Insertion(s)
TI{TI}Obp49aD
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Jeong et al., 2013)
Mutagen
cre recombinase
(Jeong et al., 2013)
Progenitor genotype
Obp49a1
(Jeong et al., 2013)
Associated Insertion(s)
TI{TI}Obp49aD
Cytology
Description

The loxP cassette containing the GAL4 driver sequence and the mini-w marker has been excised.

(Jeong et al., 2013)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show impaired avoidance of a wide array of bitter tastants including papaverine, berberine, denatonium, quinine, caffeine and strychnine in a two-way choice taste assay.

      The ability of a number of bitter chemicals (papaverine, berberine, denatonium, quinine, caffeine and strychnine) to inhibit sucrose-induced action potentials in L-type sensilla is greatly reduced in mutant flies compared to wild type.

      (Jeong et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Obp49aD is rescued by Obp49aUAS.cJa/Scer\GAL4nompA.cK

      (Jeong et al., 2013)

      Obp49aD is rescued by Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)/Scer\GAL4Gr5a.PUn

      (Jeong et al., 2013)
      Not rescued by

      Obp49aD is not rescued by Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)/Scer\GAL4Gr33a-GAL4

      (Jeong et al., 2013)

      Obp49aD is not rescued by Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)/Scer\GAL4nompA.cK

      (Jeong et al., 2013)
      Comments

      Expression of Obp49aScer\UAS.cJa under the control of Scer\GAL4nompA.cK restores normal aversion to each of the bitter compounds papaverine, berberine, denatonium, quinine, caffeine and strychnine in Obp49aD flies in a two-way choice taste assay.

      Expression of Obp49aScer\UAS.cJa under the control of Scer\GAL4nompA.cK restores the ability of the bitter compounds papaverine, berberine, denatonium, quinine, caffeine and strychnine to inhibit sucrose-induced action potentials in L-type sensilla to normal in Obp49aD flies.

      Expression of Obp49aScer\UAS.T:Hsap\MYC,T:Hsap\TM-PDGFRB under the control of Scer\GAL4Gr5a.PUn, but not under the control of either Scer\GAL4Gr33a-GAL4 or Scer\GAL4nompA.cK, restores the impaired avoidance of bitter compounds (berberine, denatonium, quinine or caffeine) seen in Obp49aD flies in a two-way choice assay.

      (Jeong et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Obp49aD
      (Jeong et al., 2013)
      obp49aD
      (Lee et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)