FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)
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General Information
Symbol
Dmel\Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)
Species
D. melanogaster
Name
FlyBase ID
FBal0290244
Feature type
allele
Associated gene
Dmel\Obp49a
Associated Insertion(s)
Carried in Construct
P{UAS-Obp49a.TM}
Key Links
Transgenic product class
wild_type
(Jeong et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Jeong et al., 2013)
Mutagen
in vitro construct
(Jeong et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Obp49a.TM}
Cytology
Description

UASt regulatory sequences drive expression of Obp49a, followed by the Tag:MYC tag and finally a transmembrane domain (Tag:TM(hPDGFRB)) to tether it to the membrane.

(Jeong et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Obp49a
Tagged with
Tag:MYC
Tag:TM(hPDGFRB)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Obp49aScer\UAS.T:Hsap\MYC,T:Hsap\TM-PDGFRB under the control of Scer\GAL4Gr5a.PUn show normal repulsion to each of the bitter tastants berberine, denatonium, quinine or caffeine in a two-way choice taste assay.

      (Jeong et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)/Scer\GAL4Gr5a.PUn rescues Obp49aD

      (Jeong et al., 2013)
      Fails to rescue

      Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)/Scer\GAL4Gr33a-GAL4 fails to rescue Obp49aD

      (Jeong et al., 2013)

      Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)/Scer\GAL4nompA.cK fails to rescue Obp49aD

      (Jeong et al., 2013)
      Comments

      Expression of Obp49aScer\UAS.T:Hsap\MYC,T:Hsap\TM-PDGFRB under the control of Scer\GAL4Gr5a.PUn, but not under the control of either Scer\GAL4Gr33a-GAL4 or Scer\GAL4nompA.cK, restores the impaired avoidance of bitter compounds (berberine, denatonium, quinine or caffeine) seen in Obp49aD flies in a two-way choice assay.

      (Jeong et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Obp49aScer\UAS.T:Hsap\MYC,T:Hsap\TM-PDGFRB
      Obp49aUAS.Tag:MYC,Tag:TM(hPDGFRB)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)