FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\2mitc03963
Open Close
General Information
Symbol
Dmel\2mitc03963
Species
D. melanogaster
Name
FlyBase ID
FBal0290399
Feature type
allele
Associated gene
Dmel\2mit
Associated Insertion(s)
PBac{PB}timeoutc03963
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Baggio et al., 2013, Benna et al., 2010)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{PB}timeoutc03963
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous adults do not have any gross morphological abnormalities and their overall brain organisation appears similar to wild type. Phototactic behaviour and locomotor activity are normal.

        Homozygous males show a defect in courtship conditioning: the courtship index of homozygous males that have previously courted non-receptive females is not significantly reduced compared to control males that have not undergone conditioning (in contrast to wild-type males, where conditioned males show a reduced courtship index compared to unconditioned controls). The training index of the homozygous males is not significantly different from that of controls, indicating that the defect is in memory rather than in learning.

        (Baggio et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        2mitc03963 is rescued by 2mitUAS.Tag:HA/Scer\GAL4elav.PU

        (Baggio et al., 2013)
        Comments

        The courtship conditioning defect seen in homozygous 2mitc03963 males is rescued by expression of 2mitScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PU.

        (Baggio et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        2mitc03963
        (Bozzato et al., 2020, Baggio et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)