FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mdlcc04701
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General Information
Symbol
Dmel\mdlcc04701
Species
D. melanogaster
Name
FlyBase ID
FBal0290442
Feature type
allele
Associated gene
Dmel\mdlc
Associated Insertion(s)
PBac{PB}mdlcc04701
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{PB}mdlcc04701
    Cytology
    Description

    Insertion in the 5' UTR, 10bp upstream of the mdlc translation start site.

    (Carney et al., 2013)
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous neuroblast clones have a longer cell cycle, resulting in a reduction in clone size, compared to wild-type control clones.

        (Carney et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        mdlcc04701/Df(3R)ED6027 has lethal phenotype, suppressible by Hsap\RNF113AUAS.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)
        Phenotype Manifest In
        Suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Expression of Hsap\RNF113AScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues the reduction in size of homozygous mdlcc04701 neuroblast clones.

        Expression of Hsap\RNF113AScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues mdlcc04701/Df(3R)ED6027 animals to viability.

        (Carney et al., 2013)
        Complementation and Rescue Data
        Rescued by

        mdlcc04701 is rescued by mdlcΔRING.UAS.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)

        mdlcc04701 is rescued by mdlcI266A.UAS.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)

        mdlcc04701/Df(3R)ED6027 is rescued by mdlcUAS.FL.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)

        mdlcc04701/Df(3R)ED6027 is rescued by mdlcΔRING.UAS.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)

        mdlcc04701/Df(3R)ED6027 is rescued by mdlcI266A.UAS.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)
        Partially rescued by

        mdlcc04701 is partially rescued by mdlcUAS.FL.Tag:HA/Scer\GAL4Tub.PU

        (Carney et al., 2013)
        Not rescued by

        mdlcc04701 is not rescued by Scer\GAL4Tub.PU/mdlcΔCCCH.UAS.Tag:HA

        (Carney et al., 2013)

        mdlcc04701 is not rescued by Scer\GAL4Tub.PU/mdlcΔCCCH+RING.UAS.Tag:HA

        (Carney et al., 2013)

        mdlcc04701/Df(3R)ED6027 is not rescued by Scer\GAL4Tub.PU/mdlcΔCCCH.UAS.Tag:HA

        (Carney et al., 2013)

        mdlcc04701/Df(3R)ED6027 is not rescued by Scer\GAL4Tub.PU/mdlcΔCCCH+RING.UAS.Tag:HA

        (Carney et al., 2013)
        Comments

        Expression of mdlcScer\UAS.FL.T:Ivir\HA1 under the control of Scer\GAL4tub.PU partially rescues the reduction in size of homozygous mdlcc04701 neuroblast clones.

        Expression of either mdlcΔRING.Scer\UAS.T:Ivir\HA1 or mdlcI266A.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues the reduction in size of homozygous mdlcc04701 neuroblast clones.

        Expression of either mdlcScer\UAS.FL.T:Ivir\HA1, mdlcI266A.Scer\UAS.T:Ivir\HA1 or mdlcΔRING.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues mdlcc04701/Df(3R)ED6027 animals to viability.

        Expression of mdlcΔCCCH.Scer\UAS.T:Ivir\HA1 or mdlcΔCCCH+RING.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU fails to rescue mdlcc04701/Df(3R)ED6027 animals to viability.

        Expression of mdlcΔCCCH.Scer\UAS.T:Ivir\HA1 or mdlcΔCCCH+RING.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU fails to rescue the reduction in size of homozygous mdlcc04701 neuroblast clones.

        (Carney et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mdlcc04701
        (Carney et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)