FB2026_02 , released June 18, 2026
Allele: Dmel\mdlcI266A.UAS.Tag:HA
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General Information
Symbol
Dmel\mdlcI266A.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0290447
Feature type
allele
Associated gene
Dmel\mdlc
Associated Insertion(s)
Carried in Construct
PBac{UAS-mdlc.I266A}
Key Links
Transgenic product class
missense_variant
(Carney et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Carney et al., 2013)
Mutagen
in vitro construct
(Carney et al., 2013)
Progenitor genotype
Carried in construct
PBac{UAS-mdlc.I266A}
Cytology
Description

UASt regulatory sequences drive expression of mdlc containing the amino acid replacement I266A in the RING domain. The protein is tagged at the N-terminal end with Tag:HA.

(Carney et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mdlc
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuroblast clones expressing mdlcI266A.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU are wild type in size.

      (Carney et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      mdlcI266A.UAS.Tag:HA/Scer\GAL4Tub.PU rescues mdlcc04701

      (Carney et al., 2013)

      mdlcI266A.UAS.Tag:HA/Scer\GAL4Tub.PU rescues mdlcc04701/Df(3R)ED6027

      (Carney et al., 2013)
      Comments

      Expression of mdlcI266A.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues mdlcc04701/Df(3R)ED6027 animals to viability.

      Expression of mdlcI266A.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues the reduction in size of homozygous mdlcc04701 neuroblast clones.

      (Carney et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MdlcI266A
      (Carney et al., 2013)
      mdlcI266A.Scer\UAS.T:Ivir\HA1
      mdlcI266A.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)