Deletion of sequence encoding the pbl PH domain.
Two copies of pblΔPH partially rescue the failure of cytokinesis seen in stage 10 pbl2/pbl3 embryos: only 54.6 +/- 4.5% of the epidermal cells are binucleate in the rescued embryos.
The defects in mesoderm development seen in pbl2/pbl3 embryos are not completely rescued by two copies of pblΔPH : the failure of the invaginated mesodermal tube to flatten down onto the ectoderm is not rescued by pblΔPH, while the number of protrusions on the mesodermal cells during the migration period between the first and second rounds of mitosis appears slightly increased and the failure of rounding of mesodermal cells is partially rescued.
