FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SNF4AγMI09417
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General Information
Symbol
Dmel\SNF4AγMI09417
Species
D. melanogaster
Name
FlyBase ID
FBal0290571
Feature type
allele
Associated gene
Dmel\SNF4Aγ
Associated Insertion(s)
Mi{MIC}SNF4AγMI09417
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Nagarkar-Jaiswal et al., 2017)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}SNF4AγMI09417
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  tauopathy
        modeled by Hsap\MAPTUAS.cWa
        (Feuillette et al., 2020)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heat-shock induced inactivation of the SNF4AγMI09417-FF.PT-EGFP allele in SNF4AγMI09417-FF.PT-EGFP/SNF4AγMI09417 mutant flies at 3 days post eclosion (using the Scer\FLP1hs.PU to induce the 'flip-flop' cassette inversion) leads to severe neurodegeneration with multiple lesions in the brain (the neurodegeneration doesn't appear to progress further as the flies age but they typically die 3-4 weeks later).

        (Nagarkar-Jaiswal et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        SNF4Agamma[+]/SNF4AγMI09417 is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

        (Feuillette et al., 2020)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        SNF4Agamma[+]/SNF4AγMI09417 is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

        (Feuillette et al., 2020)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        SNF4AγMI09417-TG4.1

        (Nagarkar-Jaiswal et al., 2017)
        Comments

        In lethality complementation tests the SNF4AγMI09417/Df(3R)e-R1 as well as SNF4AγMI09417/SNF4AγMI09417-TG4.1 flies are lethal, but SNF4AγMI09417/SNF4AγMI09417-FF.PT-EGFP flies are viable.

        (Nagarkar-Jaiswal et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        SNF4AγMI09417
        (Feuillette et al., 2020, Nagarkar-Jaiswal et al., 2017, Bellen, 2013.10.21)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)