FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DopEcRUAS.cIb
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General Information
Symbol
Dmel\DopEcRUAS.cIb
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct b of Ishimoto
FlyBase ID
FBal0290913
Feature type
allele
Associated gene
Dmel\DopEcR
Associated Insertion(s)
Carried in Construct
P{UAS-DopEcR.Ib}
Key Links
Transgenic product class
wild_type
(Ishimoto et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ishimoto et al., 2013)
Mutagen
in vitro construct
(Ishimoto et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-DopEcR.Ib}
Cytology
Description

UASt regulatory sequences drive expression of the DopEcR coding sequence.

(Ishimoto et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
DopEcR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing DopEcRScer\UAS.cIb under the control of Scer\GAL4da.PU display largely normal sensitivity to ethanol-induced sedation.

      (Petruccelli et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of DopEcRScer\UAS.cIb under the control of Scer\GAL4Mef2.247.Switch in adult mushroom body neurons (using RU486 to limit the timing of expression) restores courtship memory in a courtship conditioning assay in rut2 males.

      Expression of DopEcRScer\UAS.cIb under the control of Scer\GAL4Mef2.247.Switch in adult mushroom body neurons (using RU486 to limit the timing of expression) does not restore courtship memory in a courtship conditioning assay in rut1084 males. However, if these flies are also fed 0.01mM 20-hydroxy-ecdysone (a concentration that does not rescue courtship memory in rut1084 single mutants), significant rescue of courtship memory is seen.

      (Ishimoto et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      DopEcRUAS.cIb/Scer\GAL4DopEcR.588 rescues DopEcRc02142

      (Ishimoto et al., 2013)

      Scer\GAL4c747/DopEcRUAS.cIb rescues DopEcRc02142

      (Ishimoto et al., 2013)

      DopEcRUAS.cIb/Scer\GAL4c739 rescues DopEcRc02142

      (Ishimoto et al., 2013)
      Partially rescues

      Scer\GAL4da.PU/DopEcRUAS.cIb partially rescues DopEcRKK111211

      (Petruccelli et al., 2016)
      Fails to rescue

      Scer\GAL4Tab2-201Y/DopEcRUAS.cIb fails to rescue DopEcRc02142

      (Ishimoto et al., 2013)
      Comments

      The increased resistance to ethanol-induced sedation characteristic for adult flies expressing DopEcRKK111211 under the control of Scer\GAL4da.PU is partially suppressed by co-expression of DopEcRScer\UAS.cIb.

      (Petruccelli et al., 2016)

      Expression of DopEcRScer\UAS.cIb under the control of either Scer\GAL4DopEcR.588, Scer\GAL4c747 or Scer\GAL4c739 rescues courtship memory in DopEcRc02142 males a courtship conditioning assay.

      Expression of DopEcRScer\UAS.cIb under the control of Scer\GAL4Tab2-201Y does not rescue courtship memory in DopEcRc02142 males a courtship conditioning assay.

      (Ishimoto et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DopEcRScer\UAS.cIb
      DopEcRUAS.cIb
      Name Synonyms
      Saccharomyces cerevisiae UAS construct b of Ishimoto
      Secondary FlyBase IDs
        References (2)