FB2026_02 , released June 18, 2026
Allele: Dmel\ManfNMG2.UAS
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General Information
Symbol
Dmel\ManfNMG2.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0291170
Feature type
allele
Associated gene
Dmel\Manf
Associated Insertion(s)
Carried in Construct
P{UAS-Manf.NMG2}
Key Links
Transgenic product class
missense_variant
(Lindström et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lindström et al., 2013)
Mutagen
in vitro construct
(Lindström et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Manf.NMG2}
Cytology
Description

UAS regulates expression of Manf containing amino acid changes K43A, K45A and R95A (N-terminal Mutant Group 2, NMG2) - selected positively charged lysines and an arginine of this surface amino acid group are replaced with neutral alanines to disrupt putative lipid interactions in the cell membrane.

(Lindström et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Manf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ManfNMG2.UAS/Scer\GAL4da.G32 rescues ManfΔ96

      (Lindström et al., 2013)

      ManfNMG2.UAS/Scer\GAL469B rescues ManfΔ96

      (Lindström et al., 2013)
      Comments

      ManfNMG2.Scer\UAS expression driven by Scer\GAL4da.G32 rescues the early larval lethality of ManfΔ96 mutants, and normalizes ManfΔ96 larval dopamine to wild type levels.

      ManfNMG2.Scer\UAS expression driven by Scer\GAL469B rescues the early larval lethality of ManfΔ96 mutants.

      (Lindström et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ManfNMG2.Scer\UAS
      ManfNMG2.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)