FB2026_02 , released June 18, 2026
Allele: Dmel\Optix1
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General Information
Symbol
Dmel\Optix1
Species
D. melanogaster
Name
FlyBase ID
FBal0291400
Feature type
allele
Associated gene
Dmel\Optix
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Li et al., 2013)
Mutagen
P-element activity
(Li et al., 2013)
Progenitor genotype
P{GawB}NP2631
(Li et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 5.4kb deletion that removes part of Optix including the transcription start site and the exons encoding the Six domain and homeodomain.

(Li et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Optix1 somatic clones in an otherwise wild-type background are excluded from the neuroepithelium and form rosettes only when induced in Optix-positive expression domains in the optic lobe of late third instar larvae. The excluded cells have an elongated shape and undergo apoptosis, without showing any signs of differentiation or neurogenesis.

      (Gold and Brand, 2014)

      Homozygotes die as early larvae.

      Homozygous eyes (generated using the EGUF method) are small and kidney-shaped.

      Homozygous clones in the eye disc show normal initiation of the morphogenetic furrow, but clones which span the furrow show defects in morphogenetic furrow progression compared to surrounding wild-type tissue. Photoreceptor cell differentiation is delayed, but the mutant cells inside the clone do eventually differentiate.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Optix1 is rescued by Optix+t40

      (Li et al., 2013)
      Comments

      Optix+t40 rescues the lethality of Optix1 homozygotes and the defects of homozygous eye generated using the EGUF method.

      (Li et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Optix1
      (Arbouzova et al., 2019, Erclik et al., 2017, Gold and Brand, 2014)
      optix1
      (Li et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)