FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrg+t25
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General Information
Symbol
Dmel\Nrg+t25
Species
D. melanogaster
Name
FlyBase ID
FBal0291691
Feature type
allele
Associated gene
Dmel\Nrg
Associated Insertion(s)
Carried in Construct
P{Nrg+t25}
Also Known As
P[nrg_wt]
Key Links
Transgenic product class
genomic_DNA
(Enneking et al., 2013)
wild_type
(Enneking et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Enneking et al., 2013)
wild_type
(Enneking et al., 2013)
Mutagen
in vitro construct
(Enneking et al., 2013)
Progenitor genotype
Carried in construct
P{Nrg+t25}
Cytology
Description

A genomic fragment containing the entire Nrg locus including 25kb upstream and 10kb downstream.

(Enneking et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
Nrg
Encoded product / tool
Nrg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Nrg+t25 in a Nrgl4 mutant background establish a normal function of the adult Giant Fibre (GF)-Trochanteral Muscle (TTMn) circuit. There are no significant differences in average response latencies or following frequencies after a train of stimulations at 100 Hz when compared to wild type. No obvious morphological defects are seen at GF terminals.

      (Enneking et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Nrg+t25 rescues Nrgl4

      (Zhang et al., 2014)

      Nrg+t25 rescues Nrgl4

      (Enneking et al., 2013)

      Nrg+t25 rescues Nrgl7

      (Enneking et al., 2013)
      Comments

      Expression of Nrg+t25 fully rescues Nrgl4 mutant embryonic lethality. The axonal and NMJ defects seen in Nrgl4 mutant larval motorneuron clones are also fully rescued and similar rates of innervation are seen for all four major classes of motorneurons (SNc/d, SNb, SNa and ISN) as controls.

      Expression of Nrg+t25 fully rescues Nrgl7 mutant embryonic lethality.

      (Enneking et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Nrg+t25
      Name Synonyms
      Secondary FlyBase IDs
        References (5)