FB2026_02 , released June 18, 2026
Allele: Dmel\unc79x25
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General Information
Symbol
Dmel\unc79x25
Species
D. melanogaster
Name
FlyBase ID
FBal0293678
Feature type
allele
Associated gene
Dmel\unc79
Associated Insertion(s)
P{?GSV6}unc79x25
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lear et al., 2013)
Mutagen
P-element activity
(Lear et al., 2013)
Progenitor genotype
P{GSV6}GS9462
(Lear et al., 2013)
Associated Insertion(s)
P{?GSV6}unc79x25
Cytology
Description

Imprecise excision of the P{GSV6} element in P{GSV6}GS9462 has resulted in a 1305bp genomic deletion in unc79, while retaining 12bp of the P-element.

(Lear et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:19,240,620..19,241,924 [-]
Comment:

1305 bp deletion resulting from the imprecise excision of P{GSV6}GS9462. The deleted sequences include two coding exons of 57 and 80 bp.

(Lear et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc79x25 mutant flies exhibit severe defects in anticipatory behaviour and free-running rhythmicity in comparison to wild type flies. Similarly strong phenotypes are seen in unc79x25/Df(3R)ED5942 mutant flies.

      unc79x25/+ males do not exhibit significant behavioural rhythmicity defects in DD conditions (constant darkness) in comparison with wild type controls.

      (Lear et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      unc79x25/unc80x42 males do not exhibit significant DD (constant darkness) behavioural rhythmicity defects compared to wild type controls.

      nae04385/+;; unc79x25/+ flies do not exhibit strong behavioural rhythmicity deficits in DD conditions (constant darkness) compared to single heterozygotes.

      Expression of naScer\UAS.cLa under the control of Scer\GAL4tim.PE does not suppress the circadian behaviour defects seen in unc79x25 mutant flies.

      Expression of unc80Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tim.PE does not suppress the circadian behaviour defects seen in unc79x25 mutant flies.

      Co-expression of naScer\UAS.cLa and unc80Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tim.PE does not suppress the circadian behaviour defects seen in unc79x25 mutant flies.

      (Lear et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      unc79x25/unc79f01615 is rescued by Scer\GAL4tim.PE, unc79f01615

      (Lear et al., 2013)
      Partially rescued by

      unc79x25 is partially rescued by Scer\GAL4tim.PE/unc79UAS.Tag:MYC

      (Lear et al., 2013)
      Comments

      Expression of unc79Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tim.PE strongly rescues the circadian behaviour defects seen in unc79x25 mutant flies in both DD (constant darkness) and LD (12 hour light: 12 hour dark) conditions.

      Expression of unc79f01615 under the control of Scer\GAL4tim.PE rescues the circadian behavior defects seen in unc79x25/unc79f01615 mutant flies.

      (Lear et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      unc79 [x25]
      (Lear et al., 2013)
      unc79x25
      (Lear et al., 2013)
      unc79[x25]
      (Lear et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)