FB2026_02 , released June 18, 2026
Allele: Dmel\TpiM80T
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General Information
Symbol
Dmel\TpiM80T
Species
D. melanogaster
Name
FlyBase ID
FBal0293728
Feature type
allele
Associated gene
Dmel\Tpi
Associated Insertion(s)
TI{TI}TpiM80T
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Roland et al., 2013)
cre recombinase
(Roland et al., 2013)
Progenitor genotype
TpiattP
(Roland et al., 2013)
Associated Insertion(s)
TI{TI}TpiM80T
Cytology
Description

A mutated copy of the Tpi locus (containing the amino acid replacement M80T) has been inserted into the attP site present in TpiattP. A single attR site remains 5' and a single loxP site remains 3' to the reconstituted Tpi locus.

(Roland et al., 2013)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TpiM80T/TpiM80T, TpiM80T/TpiR187A, TpiM80T/TpiR187L, TpiM80T/TpiR187S and TpiM80T/Tpisgk-js10 individuals are bang sensitive, whereas TpiM80T/TpiR187K individuals are not.

      (Roland et al., 2019)

      TpiM80T homozygotes are partially lethal; TpiM80T homozygous and TpiM80T/Tpisgk-js10 transheterozygous adults exhibit a significant decrease in lifespan and an increase in heat sensitivity, shown by the significant decrease in the time until paralysis after a temperature shift to 38[o]C, as compared to controls; TpiM80T/Tpisgk-js10 transheterozygous adults, but not TpiM80T homozygous adults, exhibit an increase in bang sensitivity, shown by a significant increase in recovery time from mechanical stress, as compared to controls.

      (Roland et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      GE dTPIM80T
      (Roland et al., 2016)
      M80T
      (Fogle et al., 2019)
      TPIM80T
      (Roland et al., 2019, Roland et al., 2013)
      TPIM80T (attR)
      (Roland et al., 2013)
      TPIsugarkill
      (Hrizo et al., 2021)
      TpiM80T
      dTPIM80T
      (Roland et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)