FB2026_03 , released September 17, 2026
Allele: Hsap\ATXN185Q.UAS.Tag:MYC
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General Information
Symbol
Hsap\ATXN185Q.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0294006
Feature type
allele
Associated gene
Hsap\ATXN1
Associated Insertion(s)
Carried in Construct
PBac{UAS-ATXN1.85Q}
Key Links
Transgenic product class
trinucleotide_repeat_expansion
(Fujita et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Fujita et al., 2013)
Mutagen
in vitro construct
(Fujita et al., 2013)
Progenitor genotype
Carried in construct
PBac{UAS-ATXN1.85Q}
Cytology
Description

UASt regulatory sequences drive expression of the full-length Hsap\ATXN1 open reading frame containing an 85Q polyglutamine repeat. The protein is tagged with 5 copies of Tag:MYC.

(Fujita et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\ATXN1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEC
      (Fujita et al., 2013)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by TER94GS10258
      (Fujita et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Fujita et al., 2013)
      ATXN1:p.Gln197[85]
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      ATXN1:p.Gln197[85Gln]
      ATXN1, (CAG)n REPEAT EXPANSION
      Associated human disease model(s)
      External database links
      ClinVar: ATXN1_8071
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\ATXN185Q.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4RapGAP1-OK6 results in a shortened lifespan compared to controls in both males and females.

      (Fujita et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of TER94GS10258 partially rescues in males and in females the shortened lifespan caused by expression of Hsap\ATXN185Q.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4RapGAP1-OK6.

      (Fujita et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\ATXN185Q.Scer\UAS.T:Hsap\MYC
      Hsap\ATXN185Q.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)