FB2026_02 , released June 18, 2026
Allele: Dmel\SxlM1,fΔ33
Open Close
General Information
Symbol
Dmel\SxlM1,fΔ33
Species
D. melanogaster
Name
FlyBase ID
FBal0294059
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Evans and Cline, 2013)
Progenitor genotype
P{lacW}SxlM1,fPw+c
(Evans and Cline, 2013)
Cytology
Description

Imprecise excision of the progenitor P{lacW}SxlM1,fPw+c insertion results in a deletion of Sxl DNA from +3,410 to +7,947 (0 corresponds to the Sxl[[Pm]] transcription start site).

(Evans and Cline, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:7,090,106..7,094,643 [-]
Comment:

Deletion resulting from the imprecise excision of the progenitor insertion, which extends from +3410 to +7947 relative to the Sxl[[Pm]] transcription start site.

(Evans and Cline, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sxlf7,M1/SxlM1,fΔ33 females display masculinized external and internal somatic morphology and body size. The only hints of somatic femininity are a few small sixth-sternite bristles and about 25% fewer sexcomb teeth than seen in true males.

      SxlM1,fΔ33 suppresses the dominant male-specific lethality of SxlM1.

      SxlM1,fΔ33 supports wild-type oogenesis in homozygous mutant germline clones.

      Sxlf7,M1 and SxlM1,fΔ33 fail to complement for female viability if exosed to 18[o]C during early embryogenesis or if exposed to 30[o] during the pupal period.

      (Evans and Cline, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      traF.U2af50 feminizes Sxlf7,M1/SxlM1,fΔ33 mutants without increasing their size. Sxlf7,M1/SxlM1,fΔ33 ; traF.U2af50/+ females have large ovaries full of mature eggs, but they fail to lay.

      Virgin Sxlf7,M1/SxlM1,fΔ33 ; traF.U2af50/+ females rescued by traF.U2af50 do lay eggs, some depositing nearly as many eggs as some of their mated sisters.

      (Evans and Cline, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SxlM1,fΔ33
      (Evans and Cline, 2013)
      SxlfΔ33
      (Evans and Cline, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)