FB2026_02 , released June 18, 2026
Allele: Dmel\watΔR
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General Information
Symbol
Dmel\watΔR
Species
D. melanogaster
Name
FlyBase ID
FBal0294114
Feature type
allele
Associated gene
Dmel\wat
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jaspers et al., 2014)
Progenitor genotype
P{XP}d01446
(Jaspers et al., 2014)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous watΔR mutant stage 17 embryos lack tracheal tube liquid clearance.

      watΔR/Df(3R)Exel6211 mutant stage 17 embryos lack tracheal tube liquid clearance.

      watΔR/watΔG mutant stage 17 embryos lack tracheal tube liquid clearance. Tracheal morphogenesis is indistinguishable from wild type, and the components of septate junctions are also comparable. Furthermore the transepithelial barrier mediated by septate junctions is unaffected in watΔR/watΔG mutant embryos, as is the exocytosis of serp and verm. In contrast to wild type, in which the tracheal lumen shows an unstructured uniform appearance, watΔR/watΔG mutant tracheal lumens have membranous structures and such structures are occasionally associated with the outermost cuticle sublayer of the tracheal taenidial folds. The morphology of the procuticle, epicuticle and taenidial fold is similar to wild type.

      (Jaspers et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      watΔG

      (Jaspers et al., 2014)
      Partially rescued by

      watΔR is partially rescued by watUAS.cJa/Scer\GAL4btl.PS

      (Jaspers et al., 2014)

      watΔG/watΔR is partially rescued by watUAS.cJa/Scer\GAL4btl.PS

      (Jaspers et al., 2014)
      Comments

      Expression of watScer\UAS.cJa under the control of Scer\GAL4btl.PS rescues tracheal liquid clearance defects seen in 90% of watΔR or watΔG mutant embryos. When watScer\UAS.cJa expression is limited to the dorsal trunk cells using Scer\GAL4salm.TE a normal wild type phenotype is seen in 50% of watΔR or watΔG mutant embryos. If watScer\UAS.cJa is expressed in the dorsal branch and lateral trunk cells of the tracheal system under the control of Scer\GAL4kni.TE only ~4% of rescued embryos exhibit normal liquid clearance.

      (Jaspers et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      R4(d01446)
      (Jaspers et al., 2014)
      watΔR
      (Jaspers et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)